Lee SW*, Oh YM*, Victor MB, Yang Y, Chen S, Strunilin I, Dahiya S, Dolle RE, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington’s disease neurodegeneration. Nature Aging. 2024 Jan;4(1):95-109. doi: 10.1038/s43587-023-00538-3. Epub 2023 Dec 8. PMID: 38066314. *equal contribution
Oh YM, Lee SW, Yoo AS. Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration. Autophagy. 2023 Sep;19(9):2613-2615. doi: 10.1080/15548627.2023.2175572. Epub 2023 Feb 8. PMID: 36727408; PMCID: PMC10392748.
Oh YM*, Lee SW*, Kim WK, Chen S, Church VA, Cates K, Li T, Zhang B, Dolle RE, Dahiya S, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy. Nature Neuroscience. 2022 Nov;25(11):1420-1433. doi: 10.1038/s41593-022-01185-4. Epub 2022 Oct 27. PMID: 36303071. *equal contribution
Capano LS*, Sato C*, Ficulle E*, Yu A*, Horie K, Kwon J-S, Burbach KF, Barthélemy NR, Fox SG, Karch CM, Bateman RJ, Houlden H, Morimoto RI, Holtzman DM, Duff KE, and Yoo AS. Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons. Cell Stem Cell. 2022 Jun 2; 29(6):918-932. doi: 10.1016/j.stem.2022.04.018. PMID: 35659876. *equal contribution
Lu YL, Liu Y, McCoy MJ, Yoo AS. MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity. Proc Natl Acad Sci USA. 2021 Jun 1;118(22):e2015454118. doi: 10.1073/pnas.2015454118.
Church VA*, Cates K*, Capano L*, Aryal S*, Kim WK*, Yoo AS. Generation of Human Neurons by microRNA-Mediated Direct Conversion of Dermal Fibroblasts. In Methods Mol Biol. 2021; Chapter 6: 2239:77-100. doi: 10.1007/978-1-0716-1084-8_6. *: equal contributions
Franco A, Dang X, Walton EK, Ho JN, Zablocka B, Ly C, Miller TM, Baloh RH, Shy ME, Yoo AS, Dorn GW 2nd. Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A. eLife. 2020 Oct 19;9:e61119. doi: 10.7554/eLife.61119.
Cates K*, McCoy MJ*, Kwon JS*, Liu Y*, Abernathy DG, Zhang B, Liu S, Gontarz P, Kim WK, Chen S, Kong W, Ho JN, Burbach KF, Gabel HW, Morris SA, Yoo AS. Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs. Cell Stem Cell. 2020 Sep 17:S1934-5909(20)30411-2. *: Co-first authors
Fox LM, Kim K, Johnson CW, Chen S, Croce KR, Victor MB, Eenjes E, Bosco JR, Randolph LK, Dragatsis I, Dragich JM, Yoo AS, Yamamoto A. Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy. Neuron. 2020 Mar 4;105(5):813-821.
Lu, Y.L., Yoo, A.S. Mechanistic Insights Into MicroRNA-Induced Neuronal Reprogramming of Human Adult Fibroblasts. Front Neurosci. 2018. 12:522. doi:10.3389/fnins.2018.00522. eCollection 2018. Review.
Lee, S.W., Oh, Y.M., Lu, Y.L., Kim, W.K., Yoo, A.S. MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability During Neuronal Conversion of Human Adult Fibroblasts. Developmental Cell. 2018. 46(1):73-84.e7. doi: 10.1016/j.devcel.2018.06.007.
McCoy, M.J.*, Paul, A.J.*, Victor, M.B., Richner, M., Gabel, H.W., Gong, H., Yoo, A.S.*, Ahn, T.H.* LONGO: an R package for interactive gene length dependent analysis for neuronal identity. Bioinformatics. 2018 34(13):i422-i428. doi: 10.1093/bioinformatics/bty243. *: co-corresponding authors, *: co-first authors
Victor, M.B., Richner, M., Olsen, H.E., Lee, S.W., Monteys, A.M., Ma, C., Huh, C.J., Zhang, B., Davidson, B.L., Yang, X.W., Yoo, A.S. Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes. Nature Neuroscience. 2018. 3:341-352 doi: 10.1038/s41593-018-0075-7.
Abernathy, D.G.*, Kim, W.K.*, McCoy, M.J.*, Lake, A.M., Ouwenga, R., Lee, S.W., Xing, X., Li, D., Lee, H.J., Heuckeroth, R.O., Dougherty, J.D., Wang, T., Yoo, A.S. MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell Stem Cell. 2017. 21, 332-348. *: co-first authors
Liu, Y., Abernathy, D.G., Yoo, A.S. Chapter 7 Epigenetic regulation of neurogenesis by microRNAs, In: Essentials of Noncoding RNA in Neuroscience, 2017. Edited by Davide De Pietri Tonelli, Elsevier Academic Press
Huh, C.J., Zhang, B, Victor, M.B., Dahiya, S., Batista, L.F., Horvath, S., and Yoo, A.S. Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts. eLife. 2016. 5:e18648.
Richner, M.*, Victor, M.B.*, Liu, Y., Abernathy, D., and Yoo, A.S. MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons. Nature Protocols. 2015. 10, 1543-1555. *: co-first authors
Victor, M.B.*, Richner, M.*, Hermanstyne, T.O., Ransdell, J.O., Sobieski, C., Deng, P.Y., Klyachko, V.A., Nerbonne, J.M., Yoo, A.S. Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron. 2014. 84, 311-323. *: co-first authors [Featured in Neuron Best of 2014-2015]
Abernathy, D.G., and Yoo, A.S. (2014). MicroRNA-dependent genetic networks during neural development. Cell Tissue Res. 2014. 359, 179-185
Sun, A.X., Crabtree, G.R., and Yoo, A.S. (2013). MicroRNAs: regulators of neuronal fate. Curr Opin Cell Biol. 2013. 25, 215-221
Yoo, A.S.*, Sun, A.X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R.E., Tsien, R.W., and Crabtree, G.R.* MicroRNA-mediated conversion of human fibroblasts to neurons. Nature. 2011. 476, 228-231. *: corresponding authors
Yoo, A.S., Staahl, B.T., Chen, L., and Crabtree, G.R. MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature. 2009. 460, 642-646.
Yoo, A.S., and Crabtree, G.R. ATP-dependent chromatin remodeling in neural development. Current Opinion in Neurobiology. 2009. 19, 120-126.
Yoo, A.S., and Greenwald, I. LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science. 2005. 310, 1330-1333.
Yoo, A.S., Bais, C., and Greenwald, I. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science. 2004. 303, 663-666.
Yu, H., Yoo, A.S.*, and Greenwald, I. Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites. Bioinformatics, 2004. 20, 1198-1200. *: corresponding author
Yoo, A.S., Cheng, I., Chung, S., Grenfell, T.Z., Lee, H., Pack-Chung, E., Handler, M., Shen, J., Xia, W., Tesco, G., et al. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 2000. 27, 561-572.
Yoo, A.S., Krieger, C., and Kim, S.U. (1999). Process extension and intracellular Ca2+ in cultured murine oligodendrocytes. Brain Research. 1999. 827, 19-27.
Yoo, A.S., McLarnon, J.G., Xu, R.L., Lee, Y.B., Krieger, C., and Kim, S.U. Effects of phorbol ester on intracellular Ca2+ and membrane currents in cultured human microglia. Neuroscience Letters. 1996. 218, 37-40.
Yoo, A., Harris, J., and Dubrovsky, B. Dose-response study of dehydroepiandrosterone sulfate on dentate gyrus long-term potentiation. Experimental Neurology. 1996. 137, 151-156