Welcome to Andrew Yoo’s lab at Washington University School of Medicine in St. Louis.

We study the role of microRNAs and chromatin remodeling complexes in neurogenesis and devise cellular reprogramming approaches to generate human neurons by directly converting skin fibroblasts to neurons. Our goal is to model adult-onset neurodegenerative disorders with patient-derived neurons and study how aging of human neurons contributes to the vulnerability to neurodegeneration.

The picture above is an representative image of human neurons directly reprogrammed from skin cells by microRNAs and transcription factors (courtesy of L. Capano).